Conformational differences between Fuc(α1-3)GlcNAc and its thioglycoside analogue

被引：46

作者：

Aguilera, B ^{[1
]}

Jiménez-Barbero, J ^{[1
]}

Fernández-Mayoralas, A ^{[1
]}

机构：

[1] CSIC, Inst Quim Organ, Dept Quim Organ Biol, E-28006 Madrid, Spain

来源：

CARBOHYDRATE RESEARCH | 1998年 / 308卷 / 1-2期

关键词：

NOE spectroscopy; molecular mechanics calculations; thiodisaccharides; Lewis antigens; conformational analysis;

D O I：

10.1016/S0008-6215(98)00066-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NOE measurements and molecular mechanics calculations have been performed to study the conformational behaviour of Fuc(alpha 1-3)GlcNAc and its thioglycoside analogue in solution. Experimental data show that, in contrast with the natural O-disaccharide, which is basically monoconformational, the S-analogue shows two conformational families, namely syn and anti. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：19 / 27

页数：9

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