Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid are less likely to develop neutralizing antibodies against interferon beta

被引:15
作者
Lundkvist, M. [1 ]
Greiner, E. [1 ]
Hillert, J. [1 ]
Fogdell-Hahn, A. [1 ]
机构
[1] Karolinska Inst, Dept Clin Neurosci, Multiple Sclerosis Res Grp, Ctr Mol Med L8 00, SE-17176 Stockholm, Sweden
关键词
cerebrospinal fluid; interferon beta; human; multiple sclerosis; neutralizing antibodies; oligoclonal bands; IGG;
D O I
10.1177/1352458510373112
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Multiple sclerosis patients without cerebrospinal fluid oligoclonal IgG bands have been proposed to constitute an immunogenetically distinct subgroup of multiple sclerosis that may also differ in terms of prognosis. A proportion of patients with multiple sclerosis receiving IFN beta develop neutralizing antibodies, which interfere with treatment efficacy. Evidence suggests that the likelihood of developing neutralizing antibodies is partly genetically determined. Here, we hypothesized that absence of oligoclonal IgG bands reflects a property of B-cell responses in oligoclonal IgG band-negative patients characterized by a lessened propensity to develop neutralizing antibodies. We aimed to compare the development of neutralizing antibodies against IFNb between oligoclonal IgG band-negative and oligoclonal IgG band-positive multiple sclerosis patients. Treatment, oligoclonal IgG band and neutralizing antibody information was obtained for 2219 patients from the Swedish multiple sclerosis registry and the Swedish neutralizing antibody registry. Additional data on genotype was available for 532 patients. A correlation was found between oligoclonal IgG band negativity and neutralizing antibody negativity (p=0.02). This difference was confined to neutralizing antibodies against IFN beta-1a, since oligoclonal IgG band-negative patients were, to a lesser extent, neutralizing antibody positive compared with oligoclonal IgG band-positive patients if treated with IFN beta-1a (12% vs. 23%; p 0.005). No difference was observed for IFN beta-1b-treated patients (44% vs. 46%). We propose that oligoclonal IgG band-negative patients differ immunologically from oligoclonal IgG band-positive patients, potentially influenced by distinct HLA-DRB1 alleles.
引用
收藏
页码:796 / 800
页数:5
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