Neuregulin-induced association of SOS Ras exchange protein with HER2(erhB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erb62) interaction

被引：12

作者：

Goodearl, A

Viehover, A

Vartanian, T

机构：

[1] Millennium Inc, Cambridge, MA USA

[2] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[3] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

DEVELOPMENTAL NEUROSCIENCE | 2001年 / 23卷 / 01期

关键词：

erbs2; erbB3; erbB4; neuregulin; glial growth factor; differentiation factor (neu); heregulin; ARIA; glia; myelination; axonal signal; mitogen;

D O I：

10.1159/000048693

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuregulins are members of the epidermal growth factor family of related ligands that exert pleotropic effects during development on the Schwann cell lineage. The receptor complex activated by neuregulin in Schwann cells consists of HER2 (erbB2) and HER3 (erbB3). The intracellular signaling events that follow activation of the HER2/HER3 receptor complex in primary cells, and in particular in Schwann cells, are poorly understood. We have found that neuregulin induces the rapid association of the guanine nucleotide exchange factor SOS with the HER2/HER3 receptor complex. The association of SOS with the HER2/HER3 receptor complex is preceded by the rapid association of Grb2 with the HER2/HER3 receptor complex. Far Western analysis indicates that Grb2 and SOS bind exclusively to HER2 in the HER2/HER3 receptor complex. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：25 / 30

页数：6

共 47 条

[1]

BENJAMIN CW, 1994, J BIOL CHEM, V269, P31346

[2] The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system [J].