Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients

被引：97

作者：

Stellos, Konstantinos ^{[1
]}

Panagiota, Victoria ^{[1
]}

Koegel, Andreas ^{[2
]}

Leyhe, Thomas ^{[3
]}

Gawaz, Meinrad ^{[1
]}

Laske, Christoph ^{[3
]}

机构：

[1] Univ Tubingen, Med Klin 3, D-72076 Tubingen, Germany

[2] Inst Schreier, Tubingen, Germany

[3] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2010年 / 30卷 / 11期

关键词：

Alzheimer's disease; cognitive decline; dementia; platelet activation; P-selectin; VASCULAR RISK-FACTORS; DEMENTIA; PROGRESSION; STROKE;

D O I：

10.1038/jcbfm.2010.140

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular risk factors contribute to the progression of dementia in Alzheimer's disease ( AD) and influence platelet activation. However, the degree of platelet activation as a possible underlying mechanism of this progression has not been studied till now. Significantly higher baseline expression of both platelet activation biomarkers, activated glycoprotein IIb-IIIa complex and P-selectin, was observed in patients with AD with fast cognitive decline compared with AD patients with slow cognitive decline during a 1-year follow-up period. These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1817-1820; doi:10.1038/jcbfm.2010.140; published online 18 August 2010

引用

页码：1817 / 1820

页数：4

共 16 条

[1] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[2] Platelet APP isoform ratios correlate with declining cognition in AD [J].

Baskin, F ;

Rosenberg, RN ;

Iyer, L ;

Hynan, L ;

Cullum, CM .

NEUROLOGY, 2000, 54 (10) :1907-1909

[3] Fast cognitive decline at the time of dementia diagnosis:: A major prognostic factor for survival in the community [J].

Carcaillon, Laure ;

Peres, Karine ;

Pere, Jean-Jacques ;

Helmer, Catherine ;

Orgogozo, Jean-Marc ;

Dartigues, Jean-Francois .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2007, 23 (06) :439-445

[4] Altered Cerebral Hemodynamics in Early Alzheimer Disease: A Pilot Study Using Transcranial Doppler [J].

Claassen, Jurgen A. H. R. ;

Diaz-Arrastia, Ramon ;

Martin-Cook, Kristin ;

Levine, Benjamin D. ;

Zhang, Rong .

JOURNAL OF ALZHEIMERS DISEASE, 2009, 17 (03) :621-629

[5] Variability in annual mini-mental state examination score in patients with probable Alzheimer disease -: A clinical perspective of data from the consortium to establish a registry for Alzheimer's disease [J].

Clark, CM ;

Sheppard, L ;

Fillenbaum, GG ;

Galasko, D ;

Morris, JC ;

Koss, E ;

Mohs, R ;

Heyman, A .

ARCHIVES OF NEUROLOGY, 1999, 56 (07) :857-862

[6] CEREBROVASCULAR AND CARDIOVASCULAR PATHOLOGY IN ALZHEIMER'S DISEASE [J].

de la Torre, Jack C. .

NEUROBIOLOGY OF DEMENTIA, 2009, 84 :35-+

[7] Treatment of vascular risk factors is associated with slower decline in Alzheimer disease [J].

Deschaintre, Yan ;

Richard, Florence ;

Leys, Didier ;

Pasquier, Florence .

NEUROLOGY, 2009, 73 (09) :674-680

[8] Hyperresponsiveness of platelets in ischemic stroke [J].

Fateh-Moghadam, Suzanne ;

Htun, Patrik ;

Tomandl, Bernd ;

Sander, Dirk ;

Stellos, Konstantinos ;

Geisler, Tobias ;

Langer, Harald ;

Walton, Kodwo ;

Handschu, Rene ;

Garlichs, Christoph ;

Daniel, Werner G. ;

Gawaz, Meinrad .

THROMBOSIS AND HAEMOSTASIS, 2007, 97 (06) :974-978

[9] The prevention of dementia with antihypertensive treatment [J].

Forette, F ;

Seux, ML ;

Staessen, JA ;

Thijs, L ;

Babarskiene, MR ;

Babeanu, S ;

Bossini, A ;

Fagard, R ;

Gil-Extremera, B ;

Laks, T ;

Kobalava, Z ;

Sarti, C ;

Tuomilehto, J ;

Vanhanen, H ;

Webster, J ;

Yodfat, Y ;

Birkenhäger, WH .

ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (18) :2046-2052

[10] Contribution of Vascular Risk Factors to the Progression in Alzheimer Disease [J].

Helzner, Elizabeth P. ;

Luchsinger, Jose A. ;

Scarmeas, Nikolaos ;

Cosentino, Stephanie ;

Brickman, Adam M. ;

Glymour, M. Maria ;

Stern, Yaakov .

ARCHIVES OF NEUROLOGY, 2009, 66 (03) :343-348

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