PAProC: a prediction algorithm for proteasomal cleavages available on the WWW

被引：146

作者：

Nussbaum, AK ^{[1
]}

Kuttler, C ^{[1
]}

Hadeler, KP ^{[1
]}

Rammensee, HG ^{[1
]}

Schild, H ^{[1
]}

机构：

[1] Univ Tubingen, Interfak Inst Zellbiol, Immunol Abt, D-72076 Tubingen, Germany

来源：

IMMUNOGENETICS | 2001年 / 53卷 / 02期

关键词：

proteasome; cleavage prediction; algorithm; MHC; CTL epitope;

D O I：

10.1007/s002510100300

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The first version of PAProC (Prediction Algorithm for Proteasomal Cleavages) is now available to the general public. PAProC is a prediction tool for cleavages by human and yeast proteasomes, based on experimental cleavage data. It will be particularly useful for immunologists working on antigen processing and the prediction of major histocompatibility complex class I molecule (MHC I) ligands and cytotoxic T-lymphocyte (CTL) epitopes. Likewise, in cases in which proteasomal protein degradation has been indicated in disease, PAProC can be used to assess the general cleavability of disease-linked proteins. On its web site (http://www.paproc.de), background information and hyperlinks are provided for the user (e.g., to SYFPEITHI, the database for the prediction of MHC I ligands).

引用

页码：87 / 94

页数：8

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