Genetic influence on language delay in two-year-old children

被引:179
作者
Dale, PS
Simonoff, E
Bishop, DVM
Eley, TC
Oliver, B
Price, TS
Purcell, S
Stevenson, J
Plomin, R [1 ]
机构
[1] Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE5 8AF, England
[2] Univ Washington, Dept Psychol, Seattle, WA 98195 USA
[3] MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England
[4] Univ Southampton, Ctr Res Psychol Dev, Southampton SO17 1BJ, Hants, England
基金
英国医学研究理事会;
关键词
D O I
10.1038/1142
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous work suggests that most clinically significant language difficulties in children do not result from acquired brain lesions or adverse environmental experiences but from genetic factors that presumably influence early brain development. We conducted the first twin study of language delay to evaluate whether genetic and environmental factors at the lower extreme of delayed language are different from those operating in the normal range. Vocabulary at age two was assessed for more than 3000 pairs of twins. Group differences heritability for the lowest 5% of subjects was estimated as 73% in model-fitting analyses, significantly greater than the individual differences heritability for the entire sample (25%). This supports the view of early language delay as a distinct disorder. Shared environment was only a quarter as important for the language-delayed sample (18%) as for the entire sample (69%).
引用
收藏
页码:324 / 328
页数:5
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