The mechanism of axl-mediated Ebola virus infection

被引：90

作者：

Shimojima, Masayuki

Ikeda, Yasuhiro

Kawaoka, Yoshihiro

机构：

[1] Univ Tokyo, Inst Med Sci, Div Virol, Dept Microbiol & Immunol, Tokyo 1088639, Japan

[2] Univ Tokyo, Int Res Ctr Infect Dis, Inst Med Sci, Tokyo, Japan

[3] Japan Sci & Technol Agcy, CREST, Tokyo, Saitama, Japan

[4] Coll Med, Mayo Clin, Mol Med Program, Rochester, MN USA

[5] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷

关键词：

D O I：

10.1086/520594

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We previously reported that expression of the receptor-type tyrosine kinase Axl, which regulates cell survival and activation, enhances both pseudotype and live Ebola virus (EBOV) infection. To clarify the mechanistic basis of this enhancement, we created a series of Axl mutants and identified amino acids/domains necessary for this function, by using a pseudotype virus carrying the EBOV glycoprotein (GP). Analyses of the Axl mutants showed the importance of extracellular and intracellular regions for Axl functions, including ligand binding and signal transduction, in EBOV GP-mediated infection. These data suggest that EBOV uses the physiological functions of Axl to enter cells.

引用

页码：S259 / S263

页数：5

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