Place memory is intact in rats with perirhinal cortex lesions

被引：60

作者：

Glenn, MJ ^{[1
]}

Mumby, DG ^{[1
]}

机构：

[1] Concordia Univ, Dept Psychol, Montreal, PQ H4B 1R6, Canada

来源：

BEHAVIORAL NEUROSCIENCE | 1998年 / 112卷 / 06期

关键词：

D O I：

10.1037/0735-7044.112.6.1353

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Two experiments compared the effects of bilateral lesions of the hippocampal formation (HPC) or perirhinal cortex (PRh) on rats' performance of an allocentric spatial working memory task-delayed matching-to-place (DMTP) in a water maze. DMTP trials consisted of paired swims, and the hidden platform was moved to a new location on each trial. Performance was assessed with intervals between the first and second swim (i.e., retention delays) of 4, 30, 120, and 300 s. The rats received extensive presurgery training in Experiment 1 and no presurgery training in Experiment 2. In both experiments, rats with HPC lesions displayed DMTP deficits at all delays, taking longer and swimming farther to find the platform on the second swims than did sham-operated controls. By contrast, rats with PRh lesions displayed normal DMTP acquisition and performance. The results suggest that, unlike the functions of KPC, those of PRh are not critical for allocentric spatial working memory.

引用

页码：1353 / 1365

页数：13

共 47 条

[1] SPATIAL-LEARNING AND MEMORY PROCESSES - THE SEARCH FOR THEIR NEUROBIOLOGICAL MECHANISMS IN THE RAT [J].

BARNES, CA .

TRENDS IN NEUROSCIENCES, 1988, 11 (04) :163-169

[2]

BOLHUIS JJ, 1994, Q J EXP PSYCHOL-B, V47, P129

[3] Neuronal responses and recognition memory [J].

Brown, MW .

SEMINARS IN THE NEUROSCIENCES, 1996, 8 (01) :23-32

[4]

Burwell R. D., 1996, Society for Neuroscience Abstracts, V22, P1118

[5] Perirhinal and postrhinal cortices of the rat: A review of the neuroanatomical literature and comparison with findings from the monkey brain [J].

Burwell, RD ;

Witter, MP ;

Amaral, DG .

HIPPOCAMPUS, 1995, 5 (05) :390-408

[6] AFFERENT CONNECTIONS OF THE PERIRHINAL CORTEX IN THE RAT [J].

DEACON, TW ;

EICHENBAUM, H ;

ROSENBERG, P ;

ECKMANN, KW .

JOURNAL OF COMPARATIVE NEUROLOGY, 1983, 220 (02) :168-190

[7] PRESERVED RECOGNITION MEMORY FOR SMALL SETS, AND IMPAIRED STIMULUS IDENTIFICATION FOR LARGE SETS, FOLLOWING RHINAL CORTEX ABLATIONS IN MONKEYS [J].

EACOTT, MJ ;

GAFFAN, D ;

MURRAY, EA .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (09) :1466-1478

[8] 2 FUNCTIONAL COMPONENTS OF THE HIPPOCAMPAL MEMORY SYSTEM [J].

EICHENBAUM, H ;

OTTO, T ;

COHEN, NJ .

BEHAVIORAL AND BRAIN SCIENCES, 1994, 17 (03) :449-472

[9] Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat [J].

Ennaceur, A ;

Neave, N ;

Aggleton, JP .

BEHAVIOURAL BRAIN RESEARCH, 1996, 80 (1-2) :9-25

[10]

GAFFAN D, 1994, EXP BRAIN RES, V99, P411

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