Interleukin-1β activates a short STAT-3 isoform is clonal insulin-secreting cells

被引：17

作者：

Morton, NM

de Groot, RP

Cawthorne, MA

Emilsson, V

机构：

[1] Univ Buckingham, Clore Lab, Buckingham MK18 1EG, England

[2] Univ Utrecht Hosp, Dept Pulm Dis, NL-3508 GA Utrecht, Netherlands

来源：

FEBS LETTERS | 1999年 / 442卷 / 01期

关键词：

interleukin; 1; beta; signal transducer and activator of transcription 3; clonal beta-cell; interleukin 1 receptor accessory protein;

D O I：

10.1016/S0014-5793(98)01623-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-1 beta (IL-1 beta) is a potent inflammatory cytokine involved in type 1 diabetes and acts through defined IL-1 beta signaling pathways. In the present work ne describe induction of DNA binding activity to signal transducer and activator of transcription (STAT) in response to IL-1 beta in clonal insulin-secreting cells, Moreover, IL-1 beta activates a short isoform of STAT-3 that potently stimulates transcription, Immunoprecipitation studies reveal an interaction between the activated STAT3 and the IL-1 receptor accessory protein indicating an association between the two signaling pathways. This may be a novel point of transduction cross talk and an additional mechanism utilised by IL-1 beta in the pancreatic beta-cell during the process of type 1 diabetes. (C) 1999 Federation of European Biochemical Societies.

引用

页码：57 / 60

页数：4

共 32 条

[1] INTERLEUKIN-1 BETA-INDUCED NITRIC-OXIDE PRODUCTION ACTIVATES APOPTOSIS IN PANCREATIC RINM5F CELLS [J].