Synthetic studies on thiostrepton family of peptide antibiotics: synthesis of the cyclic core portion containing the dehydropiperidine, dihydroquinoline, L-valine, and masked dehydroalanine segments

被引：14

作者：

Mori, T ^{[1
]}

Tohmiya, H ^{[1
]}

Satouchi, Y ^{[1
]}

Higashibayashi, S ^{[1
]}

Hashimoto, K ^{[1
]}

Nakata, M ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 38期

关键词：

thiostrepton; dehydropiperidine; dihydroquinoline; dehydroalanine; ytterbium triflate;

D O I：

10.1016/j.tetlet.2005.07.122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclic core portion containing the dehydropiperidine, dihydroquinoline, L-valine, and masked dehydroalanine (i.e., beta-phenylselenoalanine) segments of the thiostrepton family of peptide antibiotics was synthesized via the consecutive coupling of these four segments followed by cyclization at the amide bond between the dehydropiperidine and masked dehydroalanine segments. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6423 / 6427

页数：5

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