Analysis of oxytetracycline, tetracycline, and chlortetracycline in water using solid-phase extraction and liquid chromatography-tandem mass spectrometry

被引:189
作者
Zhu, J [1 ]
Snow, DD [1 ]
Cassada, DA [1 ]
Monson, SJ [1 ]
Spalding, RF [1 ]
机构
[1] Univ Nebraska, Inst Agr & Nat Resources, Water Sci Lab, Water Ctr, Lincoln, NE 68583 USA
关键词
water analysis; oxytetracycline; tetracycline; chlortetracycline;
D O I
10.1016/S0021-9673(01)01139-6
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A method using liquid chromatography-tandem mass spectrometry has been developed for determination of trace levels of tetracycline antibiotics in ground water and confined animal feeding operation waste water. Oxytetracycline (OTC), tetracycline (TC). and chlortetracycline (CTC) were extracted from water samples using both polymeric and C-18 extraction cartridges. The addition of a buffer containing potassium phosphate and citric acid improved tetracycline recoveries in lagoon water. Method detection limits determined in reagent water fortified with 1 mug l(-1) OTC, TC, and CTC were 0.21, 0.20, and 0.28 mug l(-1). Method detection limits in lagoon water samples fortified at 20 mug l(-1) for OTC, TC, and CTC were 3.6, 3. 1, and 3.8 mug l(-1). Variability in recovery from laboratory fortified blanks ranged from 86 to 110% during routine analysis. (C) 2001 Elsevier Science BY. All rights reserved.
引用
收藏
页码:177 / 186
页数:10
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