Inhibition of the expression of VE-cadherin/catenin complex by gamma linolenic acid in human vascular endothelial cells, and its impact on angiogenesis

被引：28

作者：

Cai, J ^{[1
]}

Jiang, WG ^{[1
]}

Mansel, RE ^{[1
]}

机构：

[1] Cardiff Univ, Univ Dept Surg, Metastasis Res Grp, Cardiff CF4 4XN, S Glam, Wales

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 258卷 / 01期

关键词：

D O I：

10.1006/bbrc.1999.0596

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gamma linolenic acid (GLA) has been recently shown to inhibit tumour-induced angiogenesis, The present study investigated the effects of GLA on the HUVEC-specific adhesion. After treatment with GLA, HUVECs decreased the amounts of Triton soluble and insoluble VE-cadherin and beta-catenin and reduced tube formation in matrix in a concentration-dependent manner. An anti-VE-cadherin antibody dissociated HUVECs' colonies and exerted similar inhibitory effects on tube formation of HUVECs. These data indicate that the VE-cadherin/catenins complex is essential for formation and maintenance of new capillaries. It is concluded, therefore, that GLA inhibits tumour-induced angiogenesis partly via the decrease in the expression of VE-cadherin and beta-catenin. (C) 1999 Academic Press.

引用

页码：113 / 118

页数：6

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