Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives

被引：56

作者：

Sun, IC

Shen, JK

Wang, HK

Cosentino, LM

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] Biotech Res Labs Inc, Gaithersburg, MD 20877 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(98)00202-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eleven betulin derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Compound 4 was found to be the most active with EC50 and TI values of 0.00066 mu M and 21,515, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1267 / 1272

页数：6

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