Mobilizing endothelial progenitor cells

被引：314

作者：

Aicher, A ^{[1
]}

Zeiher, AM ^{[1
]}

Dimmeler, S ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 3, D-60590 Frankfurt, Germany

来源：

HYPERTENSION | 2005年 / 45卷 / 03期

关键词：

cardiovascular diseases;

D O I：

10.1161/01.HYP.0000154789.28695.ea

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Mobilization of endogenous endothelial progenitor cells ( EPCs) from the bone marrow may be an alternative way to increase neovascularization and may be used as therapeutic option for the treatment of ischemic cardiovascular diseases. In this review, we discuss the EPC mobilizing effects of pro- inflammatory cytokines such as granolocyte monocyte colony- stimulating factor and granulocyte colony- stimulating factor, growth factors such as vascular endothelial growth factor, placental growth factor, erythropoietin, and angiopoietin- 1, chemokines such as stromal cell - derived factor- 1, hormones such as estrogens and lipid- lowering and anti- diabetic drugs, as well as physical activity.

引用

页码：321 / 325

页数：5

共 54 条

[1] Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia [J].

Adams, V ;

Lenk, K ;

Linke, A ;

Lenz, D ;

Erbs, S ;

Sandri, M ;

Tarnok, A ;

Gielen, S ;

Emmrich, F ;

Schuler, G ;

Hambrecht, R .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (04) :684-690

[2] Endothelial nitric oxide synthase gene-deficient mice demonstrate marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast maturation and activity [J].

Aguirre, J ;

Buttery, L ;

O'Shaughnessy, M ;

Afzal, F ;

de Marticorena, IF ;

Hukkanen, M ;

Huang, P ;

MacIntyre, I ;

Polak, J .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (01) :247-257

[3] Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].

Aicher, A ;

Heeschen, C ;

Mildner-Rihm, C ;

Urbich, C ;

Ihling, C ;

Technau-Ihling, K ;

Zeiher, AM ;

Dimmeler, S .

NATURE MEDICINE, 2003, 9 (11) :1370-1376

[4] ERYTHROPOIETIN HAS A MITOGENIC AND POSITIVE CHEMOTACTIC EFFECT ON ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LEE, ES ;

KESSIMIAN, N ;

LEVINSON, R ;

STEINER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5978-5982

[5] ERYTHROPOIETIN RECEPTOR MESSENGER-RNA EXPRESSION IN HUMAN ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LIU, ZY ;

STEINER, M ;

CHIN, K ;

LEE, ES ;

KESSIMIAN, N ;

NOGUCHI, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3974-3978

[6] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[7] VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells [J].

Asahara, T ;

Takahashi, T ;

Masuda, H ;

Kalka, C ;

Chen, DH ;

Iwaguro, H ;

Inai, Y ;

Silver, M ;

Isner, JM .

EMBO JOURNAL, 1999, 18 (14) :3964-3972

[8] Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy [J].

Askari, AT ;

Unzek, S ;

Popovic, ZB ;

Goldman, CK ;

Forudi, F ;

Kiedrowski, M ;

Rovner, A ;

Ellis, SG ;

Thomas, JD ;

DiCorleto, PE ;

Topol, EJ ;

Penn, MS .

LANCET, 2003, 362 (9385) :697-703

[9] Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI) [J].

Assmus, B ;

Schächinger, V ;

Teupe, C ;

Britten, M ;

Lehmann, R ;

Döbert, N ;

Grünwald, F ;

Aicher, A ;

Urbich, C ;

Martin, H ;

Hoelzer, D ;

Dimmeler, S ;

Zeiher, AM .

CIRCULATION, 2002, 106 (24) :3009-3017

[10] Erythropoietin regulates endothelial progenitor cells [J].

Bahlmann, FH ;

de Groot, K ;

Spandau, JM ;

Landry, AL ;

Hertel, B ;

Duckett, T ;

Boehm, SM ;

Menne, J ;

Haller, H ;

Fliser, D .

BLOOD, 2004, 103 (03) :921-926

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