Diversity of protein-protein interactions

被引：653

作者：

Nooren, IMA ^{[1
]}

Thornton, JM ^{[1
]}

机构：

[1] European Bioinformat Inst, EMBL, Cambridge CB10 1SD, England

来源：

EMBO JOURNAL | 2003年 / 22卷 / 14期

关键词：

complexes; protein-protein interactions; protein structures; transient interactions;

D O I：

10.1093/emboj/cdg359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review, we discuss the structural and functional diversity of protein-protein interactions (PPIs) based primarily on protein families for which three-dimensional structural data are available. PPIs play diverse roles in biology and differ based on the composition, affinity and whether the association is permanent or transient. In vivo, the protomer's localization, concentration and local environment can affect the interaction between protomers and are vital to control the composition and oligomeric state of protein complexes. Since a change in quaternary state is often coupled with biological function or activity, transient PPIs are important biological regulators. Structural characteristics of different types of PPIs are discussed and related to their physiological function, specificity and evolution.

引用

页码：3486 / 3492

页数：7

共 22 条

[1] AN INVESTIGATION OF PROTEIN SUBUNIT AND DOMAIN INTERFACES
ARGOS, P
[J]. PROTEIN ENGINEERING, 1988, 2 (02): : 101 - 113
[2] DOMAIN SWAPPING - ENTANGLING ALLIANCES BETWEEN PROTEINS
BENNETT, MJ
CHOE, S
EISENBERG, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) : 3127 - 3131
[3] Stability of macromolecular complexes
Brooijmans, N
Sharp, KA
Kuntz, ID
[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2002, 48 (04) : 645 - 653
[4] MAD structure of Pseudomonas nautica dimeric cytochrome c552 mimicks the c4 dihemic cytochrome domain association
Brown, K
Nurizzo, D
Besson, S
Shepard, W
Moura, J
Moura, I
Tegoni, M
Cambillau, C
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 289 (04) : 1017 - 1028
[5] PRINCIPLES OF PROTEIN-PROTEIN RECOGNITION
CHOTHIA, C
JANIN, J
[J]. NATURE, 1975, 256 (5520) : 705 - 708
[6] 3-DIMENSIONAL STRUCTURES OF ALPHA-CHEMOKINES AND BETA-CHEMOKINES
CLORE, GM
GRONENBORN, AM
[J]. FASEB JOURNAL, 1995, 9 (01) : 57 - 62
[7] CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR HUMAN CATHEPSIN-D
FAUST, PL
KORNFELD, S
CHIRGWIN, JM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) : 4910 - 4914
[8] Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, AC
Bösche, M
Krause, R
Grandi, P
Marzioch, M
Bauer, A
Schultz, J
Rick, JM
Michon, AM
Cruciat, CM
Remor, M
Höfert, C
Schelder, M
Brajenovic, M
Ruffner, H
Merino, A
Klein, K
Hudak, M
Dickson, D
Rudi, T
Gnau, V
Bauch, A
Bastuck, S
Huhse, B
Leutwein, C
Heurtier, MA
Copley, RR
Edelmann, A
Querfurth, E
Rybin, V
Drewes, G
Raida, M
Bouwmeester, T
Bork, P
Seraphin, B
Kuster, B
Neubauer, G
Superti-Furga, G
[J]. NATURE, 2002, 415 (6868) : 141 - 147
[9] Structural symmetry and protein function
Goodsell, DS
Olson, AJ
[J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2000, 29 : 105 - 153
[10] Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Ho, Y
Gruhler, A
Heilbut, A
Bader, GD
Moore, L
Adams, SL
Millar, A
Taylor, P
Bennett, K
Boutilier, K
Yang, LY
Wolting, C
Donaldson, I
Schandorff, S
Shewnarane, J
Vo, M
Taggart, J
Goudreault, M
Muskat, B
Alfarano, C
Dewar, D
Lin, Z
Michalickova, K
Willems, AR
Sassi, H
Nielsen, PA
Rasmussen, KJ
Andersen, JR
Johansen, LE
Hansen, LH
Jespersen, H
Podtelejnikov, A
Nielsen, E
Crawford, J
Poulsen, V
Sorensen, BD
Matthiesen, J
Hendrickson, RC
Gleeson, F
Pawson, T
Moran, MF
Durocher, D
Mann, M
Hogue, CWV
Figeys, D
Tyers, M
[J]. NATURE, 2002, 415 (6868) : 180 - 183

← 1 2 3 →