Enzymatic removal of hyaluronan affects routing of axons in the mouse optic chiasm

被引：11

作者：

Chan, Chung-Kit

Wang, Jun

Lin, Ling

Hao, Yanli

Chan, Sun-On ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China

[2] Peking Univ, Sch Basic Med Sci, Dept Anat & Embryol, Beijing 100871, Peoples R China

来源：

NEUROREPORT | 2007年 / 18卷 / 15期

关键词：

axon guidance; CD44; extracellular matrix; hyaluronic acid; midline; retina;

D O I：

10.1097/WNR.0b013e3282efa065

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Perturbations of interaction of hyaluronan (HA) with its receptor CD44 cause multiple errors in axon routing at the mouse optic chiasm. To investigate this interaction further on the chiasm routing, we studied the axon routing after enzymatic removal of HA from slice preparations of the optic pathway. Hyaluronidase treatment produced an obvious reduction in midline crossing of the first generated axons in E13 chiasms, but had no influence on routing of the uncrossed axons in E15 and E16 slices. These findings support a direct role of HA, acting probably through CD44, on axon decussation during early phase of chiasm development, but argue against a direct function of HA on the turning of uncrossed axons in the mouse optic chiasm.

引用

页码：1533 / 1538

页数：6

共 21 条

[1] Identification of CD44 residues important for hyaluronan binding and delineation of the binding site [J].