Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

被引：11

作者：

Covassin, L

Desjardins, M

Soulet, D

Charest-Gaudreault, R

Audette, M

Poulin, R ^{[1
]}

机构：

[1] Univ Laval, Fac Med, Dept Physiol, St Foy, PQ G1K 7P4, Canada

[2] Univ Laval, Fac Med, Fac Pharm, St Foy, PQ G1K 7P4, Canada

[3] Univ Laval, Fac Med, Dept Pharmacol, St Foy, PQ G1K 7P4, Canada

[4] Univ Laval, Fac Med, Dept Med Biol, St Foy, PQ G1K 7P4, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0960-894X(03)00668-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3267 / 3271

页数：5

共 35 条

[1] INCREASED SURVIVAL OF L1210 LEUKEMIC MICE BY PREVENTION OF THE UTILIZATION OF EXTRACELLULAR POLYAMINES - STUDIES USING A POLYAMINE-UPTAKE MUTANT, ANTIBIOTICS AND A POLYAMINE-DEFICIENT DIET [J].