The central cannabinoid receptor inactivation suppresses endocrine reproductive functions

被引：130

作者：

Wenger, T

Ledent, C

Csernus, V

Gerendai, I

机构：

[1] Semmelweis Univ, Dept Human Morphol, H-1450 Budapest, Hungary

[2] Hungarian Acad Sci, Neuroendocrine Res Lab, Dept Human Morphol, Budapest, Hungary

[3] Univ Libre Brussels, IRIBHN, Brussels, Belgium

[4] Univ Pecs, Dept Human Anat, Pecs, Hungary

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 284卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

cannabinoid receptors; knockout mouse; luteinizing hormone; testosterone; pituitary; testis; immunohistochemistry; radioimmunoassay;

D O I：

10.1006/bbrc.2001.4977

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of central cannabinoid (CB1) receptor was investigated in the regulation of the pituitary-gonad axis in CB1 receptor knockout male mouse. Serum luteinizing hormone (LH) and testosterone (T) levels and basal T secretion in vitro of testes were significantly decreased in mutant (CB1-/-) mice. The receptor agonist, anandamide (ANA), suppressed LH and T secretion in wild type (CB1+/+) mice but had no effect in receptor inactivated animals. The results are the first descriptions indicating the direct action of CB, receptors on LH and T secretion and the immunohistological demonstration of CB1 receptors in the Leydig cells. The results also indicate that CB1 receptors are responsible for the effects of exogenous cannabinoids on reproductive functions. (C) 2001 Academic Press.

引用

收藏

页码：363 / 368

页数：6

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