In vitro bactericidal activity of antibiotic combinations against clinical isolates of mycobacterium chelonae

被引：8

作者：

Cremades, R. ^{[1
]}

Santos, A. ^{[1
]}

Rodriguez, J. C. ^{[1
]}

Garcia-Pachon, E. ^{[2
]}

Ruiz, M. ^{[1
]}

Royo, G. ^{[1
]}

机构：

[1] Univ Miguel Hernandez, Hosp Gen Univ, Microbiol Sect, E-03203 Elche, Spain

[2] Univ Miguel Hernandez, Hosp Gen Univ, Sect Pneumol, E-03203 Elche, Spain

来源：

JOURNAL OF CHEMOTHERAPY | 2008年 / 20卷 / 01期

关键词：

Mycobacteriuim chelonae; clarithromycin; quinolones;

D O I：

10.1179/joc.2008.20.1.43

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mycobacterium chelonae is one of the most antibiotic-resistant species of the pathogenic, rapidly-growing mycobacteria. The objective of this study was to evaluate the bactericidal activity of classical and new potential drugs, alone and in combinations, against clinical isolates of Mycobacterium chelonae. Clarithromycin was seen to be the most bactericidal drug. In drug combinations, this compound is most useful with gentamicin, fluoroquinolones, rifampicin, linezolid, other aminoglycosides, doxycyline and carbapenems. The combination of tobramycin with ciprofloxacin or moxifloxacin also exhibits similar activity. In conclusion, this study on bactericidal activity of drug combinations against Mycobacterium chelonae confirms the utility of clarithromycin associated with other drugs, and, of the new drugs, the value of moxifloxacin and linezolid.

引用

页码：43 / 47

页数：5

共 27 条

[1]

Aberg J A, 2001, HIV Clin Trials, V2, P453

[2] Emergence of Mycobacterium avium populations resistant to macrolides during experimental chemotherapy [J].

Bermudez, LE ;

Petrofsky, M ;

Kolonoski, P ;

Young, LS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (01) :180-183

[3] Successful treatment of disseminated Mycobacterium chelonae infection with linezolid [J].

Brown-Elliot, BA ;

Wallace, RJ ;

Blinkhorn, R ;

Crist, CJ ;

Mann, LB .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (08) :1433-1434

[4] Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria [J].

Brown-Elliott, BA ;

Wallace, RJ ;

Crist, CJ ;

Mann, L ;

Wilson, RW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (10) :3283-3285

[5]

BROWNELLIOTT BA, 2002, CLIN MICROBIOL REV, V716, P746

[6] The value of in vitro drug activity and pharmacokinetics in predicting the effectiveness of antimycobacterial therapy: A critical review [J].

Burman, WJ .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1997, 313 (06) :355-363

[7] Long-term outcomes of treatment of Mycobacterium avium complex bacteremia using a clarithromycin-containing regimen [J].

Burman, WJ ;

Stone, BL ;

Rietmeijer, CA ;

Maslow, J ;

Cohn, DL ;

Reves, RR .

AIDS, 1998, 12 (11) :1309-1315

[8]

Campbell I, 2000, THORAX, V55, P210

[9]

Fodor T, 1999, INT J TUBERC LUNG D, V3, P174

[10]

Heginbothom ML, 2001, INT J TUBERC LUNG D, V5, P539

← 1 2 3 →