DNA-microarrays: novel techniques to study aging and guide gerontologic medicine

被引：15

作者：

Helmberg, A ^{[1
]}

机构：

[1] Univ Innsbruck, Inst Gen & Expt Pathol, A-6020 Innsbruck, Austria

来源：

EXPERIMENTAL GERONTOLOGY | 2001年 / 36卷 / 07期

基金：

奥地利科学基金会;

关键词：

microarray; gene chip; single nucleotide polymorphism; aging; pathophysiology;

D O I：

10.1016/S0531-5565(01)00091-2

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

DNA array technology is a high throughput application of nucleic acid hybridization. Arrays currently used include spotted cDNA arrays at various densities and oligonucleotide arrays, where the highest densities can be obtained by synthesizing oligonucleotides directly on the solid support. While cDNA arrays can only determine the presence of a specific sequence in a sample, oligonucleotide arrays additionally allow detection of mutations and polymorphisms, including single nucleotide polymorphisms. Microarray technology can be expected to further our understanding of the aging process and to soon influence medical decision-making in age-related diseases, as well as Lifestyle decisions of consequence to the aging process. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1189 / 1198

页数：10

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