Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride

被引：121

作者：

Yasuhara, A ^{[1
]}

Kanamori, Y ^{[1
]}

Kaneko, M ^{[1
]}

Numata, A ^{[1
]}

Kondo, Y ^{[1
]}

Sakamoto, T ^{[1
]}

机构：

[1] Tohoku Univ, Fac Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 04期

关键词：

D O I：

10.1039/a808842j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.

引用

页码：529 / 534

页数：6

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