Inhibitory effect on the alpha-glucosidase reaction by the aggregated state of sulfoquinovosyldiacylglycerol

被引：8

作者：

Kurihara, H ^{[1
]}

Mitani, T ^{[1
]}

Kawabata, J ^{[1
]}

Hatano, M ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC AGR, KITA KU, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 03期

关键词：

SQDG; inhibition; alpha-glucosidase; aggregation;

D O I：

10.1271/bbb.61.536

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inhibitory activity of aggregated SQDG toward the alpha-glucosidase reaction decreased,vith increasing turbidity of the SQDG suspension, Dideacylated derivatives of SQDG, sulfoquino-vosylglycerol and sulfoquinovose, showed no inhibition toward the reaction, The expression of inhibition by the SQDG family would require a hydrophobic acyl group(s) to produce an aggregate and/or interact with a hydrophobic site in the enzyme.

引用

页码：536 / 538

页数：3

共 8 条

[1] DICKINSON E, 1982, COLLOIDS FOOD, P125
[2] STUDIES ON CHLOROPLAST MEMBRANES .3. C-13 CHEMICAL-SHIFTS AND LONGITUDINAL RELAXATION-TIMES OF 1,2-DIACYL-3-(6-SULPHO-ALPHA-QUINOVOSYL)-SN-GLYCEROL
JOHNS, SR
LESLIE, DR
WILLING, RI
BISHOP, DG
[J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (01) : 65 - 72
[3] Digalactosyldiacylglycerol suppression of inhibition by sulfoquinovosyldiacylglycerol of alpha-glucosidase
Kurihara, H
Tada, S
Takahashi, K
Hatano, M
[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1996, 60 (05) : 932 - 933
[4] SULFOQUINOVOSYLDIACYLGLYCEROL AS AN ALPHA-GLUCOSIDASE INHIBITOR
KURIHARA, H
ANDO, J
HATANO, M
KAWABATA, J
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (12) : 1241 - 1244
[5] KURIHARA H, 1996, J JPN OIL CHEM SOC, V45, P347
[6] GLYCOSIDE HYDROLASES - MECHANISTIC INFORMATION FROM STUDIES WITH REVERSIBLE AND IRREVERSIBLE INHIBITORS
LEGLER, G
[J]. ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1990, 48 : 319 - 384
[7] VandenBroek LAGM, 1996, J PHARM PHARMACOL, V48, P172, DOI 10.1111/j.2042-7158.1996.tb07117.x
[8] AMINO-SUGAR GLYCOSIDASE INHIBITORS - VERSATILE TOOLS FOR GLYCOBIOLOGISTS
WINCHESTER, B
FLEET, GWJ
[J]. GLYCOBIOLOGY, 1992, 2 (03) : 199 - 210

← 1 →