Ti(NMe2)4 as a precatalyst for hydroamination of alkynes with primary amines

被引:152
作者
Shi, YH [1 ]
Ciszewski, JT [1 ]
Odom, AL [1 ]
机构
[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
关键词
D O I
10.1021/om010566b
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Hydroaminations of carbon-carbon triple bonds with primary amines are catalyzed with commercially available Ti(NMe2)(4). The reaction is surprisingly fast with many substrates and often selective for the Markovnikov product with terminal alkynes. The scope of the catalysis was investigated with a variety of amines and alkynes; arylamines and 1-hexyne were found to be especially good substrates.
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页码:3967 / 3969
页数:3
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