Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization

被引：193

作者：

Wiseman, JM

Puolitaival, SM

Takáts, Z

Cooks, RG ^{[1
]}

Caprioli, RM

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 43期

关键词：

imaging agents; ionization; mass spectrometry; phospholipids;

D O I：

10.1002/anie.200502362

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) Direct chemical profiling of biological tissues, including metastatic human-liver adenocarcinorna, was carried out by using mass spectrometry under ambient conditions. Desorption electrospray ionization revealed enhanced signals from sphingolipids and increased unsaturation levels of the phospholipids in the tumor region of the tissue (see picture). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7094 / 7097

页数：4

共 29 条

[1]

Aboagye EO, 1999, CANCER RES, V59, P80

[2]

Athar Mohammad, 2002, Indian Journal of Experimental Biology, V40, P656

[3]

BENNINGHOVEN A, 1987, 2 ION MASS SPECTROME

[4]

Bergelson L D, 1972, Prog Chem Fats Other Lipids, V13, P1