Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

被引：91

作者：

Cocuzza, AJ

Chidester, DR

Culp, S

Fitzgerald, L

Gilligan, P

机构：

[1] Dupont Merck Pharmaceut Co, Expt Stn, Chem & Phys Sci Dept, Wilmington, DE 19880 USA

[2] Dupont Merck Pharmaceut Co, Expt Stn, Dept Biol Sci, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(99)00133-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands. (C) 1999 (C) 1999 DuPont Pharmaceuticals. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1063 / 1066

页数：4

共 15 条

[1]

ALI NM, 1992, TETRAHEDRON, V48, P8177

[2]

ARVANITIS A, 1999, IN PRESS J MED CHEM, V42

[3]

Chen C, 1996, J MED CHEM, V39, P4358

[4]

Chen Y. L., 1994, PCT Int. Appl., Patent No. 9413677

[5] Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: A centrally active corticotropin-releasing factor(1) receptor antagonist [J].

Chen, YL ;

Mansbach, RS ;

Winter, SM ;

Brooks, E ;

Collins, J ;

Corman, ML ;

Dunaiskis, AR ;

Faraci, WS ;

Gallaschun, RJ ;

Schmidt, A ;

Schulz, DW .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (11) :1749-1754

[6]

CHEN YL, 1995, Patent No. 9413650

[7]

CHEN YL, 1994, Patent No. 9413676

[8]

CHORVAT RJ, 1999, IN PRESS J MED CHEM, V42

[9] Corticotrophin-releasing factor receptor antagonists [J].

Christos, TE ;

Arvanitis, A .

EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (02) :143-152

[10] 4-aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists [J].

Cocuzza, AJ ;

Hobbs, FW ;

Arnold, CR ;

Chidester, DR ;

Yarem, JA ;

Culp, S ;

Fitzgerald, L ;

Gilligan, PJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (07) :1057-1062

← 1 2 →