A mite subversive: cleavage of CD23 and CD25 by Der p I enhances allergenicity

被引：141

作者：

Shakib, F ^{[1
]}

Schulz, O ^{[1
]}

Sewell, H ^{[1
]}

机构：

[1] Univ Nottingham, Fac Med & Hlth Sci, Queens Med Ctr, Div Mol & Clin Immunol, Nottingham NG7 2UH, England

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(98)01284-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The dust mite Dermatophagoides pteronyssinus is a major cause of allergic disease in the Western world. Der p 1 is considered to be the most immunodominant allergen involved in the expression of IgE-mediated dust-mite hypersensitivity. Here, Farouk Shakib and colleagues suggest that it is the proteolytic effect of Der p 1 on CD23 and CD25 which makes it such a potent inducer of IgE synthesis.

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页码：313 / 316

页数：4

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