Prevalence and familial aggregation of schistosomal liver morbidity in Kenya: Evaluation by new ultrasound criteria

被引:22
作者
Kariuiki, HC
Mbugua, G
Magak, P
Bailey, JA
Muchiri, EM
Thiongo, FW
King, CH
Butterworth, AE
Ouma, JH
Blanton, RE
机构
[1] Case Western Reserve Univ, Div Geog Med, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA
[3] Kenya Minist Hlth, Div Vector Borne Dis, Nairobi, Kenya
[4] Kenya Minist Hlth, Off Radiol Serv, Nairobi, Kenya
[5] Kenya Med Res Inst, Ctr Microbiol Res, Nairobi, Kenya
关键词
D O I
10.1086/319247
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Severe periportal fibrosis is not an inevitable consequence of infection with Schistosoma mansoni. Genetic predisposition may be a deciding factor in the development of disease. To assess the contribution of genetic factors in the severity of hepatic fibrosis, the degree of familial aggregation was determined in a Kenyan population. Schistosomal fibrosis was identified with hepatic ultrasound and newly proposed World Health Organization criteria, which include both qualitative and quantitative observations. These 2 aspects of the criteria correlated well with one another. The peak prevalence of ultrasound proven fibrosis trailed 5-10 years behind peak prevalence of infection and declined sharply after age 50 years. This pattern was consistent with either resolution of severe fibrosis over 10-20 years or early death of those severely affected. Genetic predisposition appears to be a weak factor in the development of severe disease in this population, since no household or familial aggregation could be identified.
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页码:960 / 966
页数:7
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