Immunotherapy for Alzheimer's disease:: attacking amyloid-β from the inside

被引：15

作者：

Arbel, Michal ^{[1
]}

Solomon, Beka ^{[1
]}

机构：

[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 12期

关键词：

D O I：

10.1016/j.it.2007.09.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although extracellular A beta plaques are a hallmark of Alzheimer's disease, it remains to be determined whether extracellular or intracellular A beta accumulation initiates the disease process. A recent paper from Gunnar Gouras' group showed that A beta antibodies lead to reduced intracellular AD levels in neurons via antibody internalization after binding to the A beta domain of amyloid precursor protein (APP) at the plasma membrane. This work suggests novel avenues for the immunotherapy of Alzheimer's disease.

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收藏

页码：511 / 513

页数：3

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