Biochemical characteristics of a human myeloid leukemia cell differentiation factor

被引:6
作者
Xu, W [1 ]
Chiao, JW [1 ]
机构
[1] NEW YORK MED COLL,DEPT MED,VALHALLA,NY 10595
关键词
D O I
10.1080/10826069608000047
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A human lymphocyte-derived maturation-inducing activity, which mediates the differentiation of human myeloid leukemia cells HL-60 to monocytic cells, was purified and characterized. The maturation inducer is a single polypeptide with a molecular mass of 54,300 Daltons. A PI range of 8.0-8.5 was determined along with the amino acid composition of the inducer. In cell cultures, the purified inducer mediated a growth reduction and a differentiation of leukemia cells to mature monocytes-macrophages, possessing complement receptors and phagocytic capacity.
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页码:21 / 30
页数:10
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