Human platelet FcγRIIA and phagocytes in immune-complex clearance

被引：31

作者：

Huang, Zhen-Yu ^{[1
]}

Chien, Paul ^{[1
]}

Indik, Zena K. ^{[1
]}

Schreiber, Alan D. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Div Hematol Oncol, Philadelphia, PA 19104 USA

来源：

MOLECULAR IMMUNOLOGY | 2011年 / 48卷 / 04期

关键词：

Platelets; Immune-complexes; Fc gamma receptor; Phagocytosis; Phagocytes; Transgenic mice; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNOGLOBULIN-G; TISSUE-INJURY; RECEPTOR; IGG; THROMBOCYTOPENIA; ANTIBODIES;

D O I：

10.1016/j.molimm.2010.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In addition to their primary role in hemostasis and wound healing, platelets play important roles in a multitude of physiological functions including immune and inflammatory responses. We present data that platelets, by virtue of their expression of the human specific Fc gamma R, Fc gamma RIIA, bind IgG complexes in vivo and that circulating phagocytes from healthy individuals internalize platelets in vivo. Human platelets, as a consequence of their expression of Fc gamma RIIA, may thus, contribute to the clearance of IgG-containing complexes from the circulation. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：691 / 696

页数：6

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