HPV testing is not useful for LSIL triage - But stay tuned

被引:5
作者
Stoler, MH [1 ]
机构
[1] Univ Virginia, Dept Pathol, Robert E Fechner Lab Surg Pathol, Charlottesville, VA 22903 USA
关键词
LSIL; cervical intraepithelial lesion (CIN) I; human papillomavirus (HPV); Triage; Atypical squamous cells of undetermined significance/low-grade; squamous intraepithelial lesions triage study (ALTS);
D O I
10.1097/00125480-200105000-00004
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The first analysis from the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (ALTS) enrollment database was a correlative analysis of human papillomavirus prevalence in patients with low-grade squamous intraepithelial lesion (LSIL) cytology. Of 642 women with an LSIL diagnosis who had analyzable Hybrid Capture II results, 82.9% of the women (95% confidence interval (CI) = 79.7 to 85.7%) had a positive result for the high-risk probe mix used in this assay. This high frequency of high-risk HPV positivity was confirmed by independent polymerase chain reaction assays on a subset of 210 of these patients with a very high concordance. Because of this finding, the potential for this HPV assay to effectively triage a population of women with an LSIL diagnosis is obviously limited. This study supports a growing consensus that the earlier reports suggesting that low-grade dysplasias were highly associated with low-risk HPV viral types were incorrect. Most of the mucosotropic viral infections that occur in the uterine cervix are high-risk viral types. Furthermore, most of these "high-risk" viral infections produce only low-grade lesions which are transient and not productive of high-grade dysplasia. Thus, the term "high-risk" or "oncogenic" HPV is a relative misnomer.
引用
收藏
页码:160 / 164
页数:5
相关论文
共 25 条
  • [1] Cavuslu S, 1996, J MED VIROL, V49, P319, DOI 10.1002/(SICI)1096-9071(199608)49:4&lt
  • [2] 319::AID-JMV10&gt
  • [3] 3.0.CO
  • [4] 2-5
  • [5] Comparison of the hybrid capture tube test and PCR for detection of human papillomavirus DNA in cervical specimens
    Cope, JU
    Hildesheim, A
    Schiffman, MH
    Manos, MM
    Lorincz, AT
    Burk, RD
    Glass, AG
    Greer, C
    Buckland, J
    Helgesen, K
    Scott, DR
    Sherman, ME
    Kurman, RJ
    Liaw, KL
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (09) : 2262 - 2265
  • [6] Evaluating the role of HPV testing for women with equivocal Papanicolaou test findings
    Cox, JT
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (17): : 1645 - 1647
  • [7] Cox JT, 1998, J FAM PRACTICE, V46, P121
  • [8] HUMAN PAPILLOMAVIRUS TESTING BY HYBRID CAPTURE APPEARS TO BE USEFUL IN TRIAGING WOMEN WITH A CYTOLOGIC DIAGNOSIS OF ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE
    COX, JT
    LORINCZ, AT
    SCHIFFMAN, MH
    SHERMAN, ME
    CULLEN, A
    KURMAN, RJ
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 172 (03) : 946 - 954
  • [9] Kjaer SK, 1996, INT J CANCER, V65, P601, DOI 10.1002/(SICI)1097-0215(19960301)65:5<601::AID-IJC8>3.0.CO
  • [10] 2-6