Genetics of mental retardation

被引：33

作者：

Chiurazzi, P

Oostra, BA

机构：

[1] Erasmus Univ, Dept Clin Genet, NL-3000 DR Rotterdam, Netherlands

[2] Univ Hosp Messina, Inst Med Prevent & Social Pediat, Messina, Italy

来源：

CURRENT OPINION IN PEDIATRICS | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1097/00008480-200012000-00003

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim of this review is to present the latest advances in the identification of the genetic determinants of intellectual deficiency. Mental retardation (MR) is often associated with other neurologic symptoms, metabolic disorders, or malformation syndromes. The purpose of the review is to subdivide the large field of MR into categories that may help professionals in making a diagnosis, Nonspecific MR can also segregate in families and the mapping and cloning of corresponding mutant genes will eventually advance our understanding of normal and abnormal brain functioning. Several genes responsible for nonspecific X-linked mental retardation have been identified in the last 12 to 24 months and are being intensively investigated, This will hopefully lead to new possibilities of either genetic or pharmacological therapy. (C) 2000 Lippincott Williams & Wilkins, Inc.

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页码：529 / 535

页数：7

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