Antineutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus

被引:9
作者
Bakkaloglu, A [1 ]
Topaloglu, R [1 ]
Saatci, U [1 ]
Ozdemir, S [1 ]
Ozen, S [1 ]
Bassoy, Y [1 ]
Besbas, N [1 ]
机构
[1] Hacettepe Univ, Sch Med, Dept Pediat Nephrol & Rheumatol, TR-06100 Ankara, Turkey
关键词
antineutrophil cytoplasmic antibodies (ANCA); myeloperoxidase (MPO); p-ANCA; c-ANCA; proteinase 3 (PR3); systemic lupus erythematosus (SLE);
D O I
10.1007/BF01451065
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We aimed to evaluate the presence of peripheral antineutrophil cytoplasmic antibodies (p-ANCA) and cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) in children with SLE and to correlate its association of laboratory findings. Twenty-one children with SLE were studied. Serum samples in patients were tested by indirect immunofluorescence (IIF) slide kit (INOVA) for c-ANCA and p-ANCA and by ELISA for myeloperoxidase (MPO-ANCA) and proteinase 3 (PR3-ANCA). All the patients but two were quiescent for lupus at the time of sampling. Sixteen of 21 patients showed positive IIF staining whereas only 5 had MPO-ANCA and 2 of nine PR3-ANCA. The data suggests that SLE may be associated p-ANCA directed against additional target antigens rather than MPO and may be implicated in the pathogenesis of SLE or may be only non-specific antibodies developed in lupus.
引用
收藏
页码:265 / 267
页数:3
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