Circulating endothelial progenitor cells during human pregnancy

被引：64

作者：

Sugawara, J ^{[1
]}

Mitsui-Saito, M ^{[1
]}

Hoshiai, T ^{[1
]}

Hayashi, C ^{[1
]}

Kimura, Y ^{[1
]}

Okamura, K ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med,Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2005年 / 90卷 / 03期

关键词：

D O I：

10.1210/jc.2004-0541

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The precise molecular and cellular mechanisms that regulate maternal vascular development during gestation are largely unknown. Endothelial progenitor cells ( EPCs), which play an important role in vascular homeostasis, have been discovered in the circulation. We examined the level of circulating EPCs throughout uncomplicated pregnancies ( n = 20) and assessed the correlation between serum estradiol levels and the number of EPCs. The number of circulating EPCs increased gradually and paralleled the progression of gestational age. In addition, the number of EPCs correlated significantly with the level of serum estradiol. The present study suggests that EPCs may play an important role in the regulation and maintenance of the placental development and vascular integrity during pregnancy.

引用

收藏

页码：1845 / 1848

页数：4

相关论文

共 24 条

[1] Mechanism for IL-1β-mediated neovascularization unmasked by IL-1β knock-out mice [J].

Amano, K ;

Okigaki, M ;

Adachi, Y ;

Fujiyama, S ;

Mori, Y ;

Kosaki, A ;

Iwasaka, T ;

Matsubara, H .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 36 (04) :469-480

[2] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[3] Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[4] VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells [J].

Asahara, T ;

Takahashi, T ;

Masuda, H ;

Kalka, C ;

Chen, DH ;

Iwaguro, H ;

Inai, Y ;

Silver, M ;

Isner, JM .

EMBO JOURNAL, 1999, 18 (14) :3964-3972

[5]

BREIER G, 1995, DEV DYNAM, V18, P43

[6] NONINVASIVE DETECTION OF ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADULTS AT RISK OF ATHEROSCLEROSIS [J].

CELERMAJER, DS ;

SORENSEN, KE ;

GOOCH, VM ;

SPIEGELHALTER, DJ ;

MILLER, OI ;

SULLIVAN, ID ;

LLOYD, JK ;

DEANFIELD, JE .

LANCET, 1992, 340 (8828) :1111-1115

[7] Autologous culture-modified mononuclear cells confer vascular protection after arterial injury [J].

Gulati, R ;

Jevremovic, D ;

Peterson, TE ;

Witt, TA ;

Kleppe, LS ;

Mueske, CS ;

Lerman, A ;

Vile, RG ;

Simari, RD .

CIRCULATION, 2003, 108 (12) :1520-1526

[8] Endothelial precursor cells in the peripheral blood of pregnant women [J].

Gussin, HAE ;

Bischoff, FZ ;

Hoffman, R ;

Elias, S .

JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 2002, 9 (06) :357-361

[9] Circulating endothelial progenitor cells, vascular function, and cardiovascular risk [J].

Hill, JM ;

Zalos, G ;

Halcox, JPJ ;

Schenke, WH ;

Waclawiw, MA ;

Quyyumi, AA ;

Finkel, T .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07) :593-600

[10]

IWAKURA A, 2003, CIRCULATION, V108, pR144