Pre-EMTing metastasis?: Recapitulation of morphogenetic processes in cancer

被引：211

作者：

Berx, Geert

Raspe, Eric

Christofori, Gerhard

Thiery, Jean Paul

Sleeman, Jonathan P.

机构：

[1] Forschungszentrum Karlsruhe, Inst Toxikol & Genet, D-76021 Karlsruhe, Germany

[2] Univ Ghent VIB, Dept Mol & Biomed Res Mol & Cellular Oncol, B-9052 Ghent, Belgium

[3] Univ Ghent VIB, Dept Mol Biol, Ghent, Belgium

[4] Univ Basel, Ctr Biomed, Inst Biochem & Genet, Dept Clin & Biol Sci, Basel, Switzerland

[5] Inst Mol & Cell Biol, Singapore 138673, Singapore

来源：

CLINICAL & EXPERIMENTAL METASTASIS | 2007年 / 24卷 / 08期

关键词：

epithelial-mesenchymal transition; metastasis; snail; E-cadherin; ILEI; podoplanin;

D O I：

10.1007/s10585-007-9114-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

EMT (epithelial-mesenchymal transition) is a morphogenetic process in which cells loose their epithelial characteristics and gain mesenchymal properties during embryogenesis. Similar processes regulated by similar pathways are recapitulated during tumour progression, endowing cells with invasive properties, thereby contributing to the formation of metastases. In this review, we outline key features of EMT and discuss the evidence for its involvement in the dissemination of tumours. Finally we review the recent literature concerning the mechanisms that regulate EMT in the tumour context, with a particular focus on breast cancer.

引用

页码：587 / 597

页数：11

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