Doublecortin-like kinase is associated with microtubules in neuronal growth cones

被引：79

作者：

Burgess, HA ^{[1
]}

Reiner, O ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2000年 / 16卷 / 05期

关键词：

D O I：

10.1006/mcne.2000.0891

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Doublecortin-like kinase (DCLK) shares sequence similarity to Doublecortin (DCX) in its N-terminal region. It contains the evolutionary conserved DC repeat: motif as well a C-terminal kinase domain. Ectopic expression of DCLK in COS cells results in colocalization with microtubules, and phosphorylated DCLK copurifies with microtubules during assembly from embryonic brain extract. During brain development DCLK is expressed mainly in postmigratory neurons in a similar pattern to DCX. We demonstrate that DCLK is a microtubule-associated active protein kinase expressed in growth cones of postmitotic neurons.

引用

页码：529 / 541

页数：13

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