Diurnal variation in serotonin immunoreactivity in the dorsal raphe nucleus

被引：14

作者：

Birkett, M

Fite, KV

机构：

[1] Univ Massachusetts, Dept Neurosci, Amherst, MA 01003 USA

[2] Univ Massachusetts, Behav Program, Amherst, MA 01003 USA

来源：

BRAIN RESEARCH | 2005年 / 1034卷 / 1-2期

基金：

美国国家科学基金会;

关键词：

5-HT immunocytochemistry; optical density analysis; mongolian gerbil;

D O I：

10.1016/j.brainres.2004.11.053

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin (5-HT) immumostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and highest IOD values occurring at the light/dark and dark/light transitions, respectively. The injection of pargyline and tryptophan increased 5-HT immunostaining comparable to the highest level observed in control animals. Transitions between light and dark periods appear to be major environmental events that influence 5-HT levels in the DRN. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：180 / 184

页数：5

共 44 条

[1] Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders [J].