Increasing the local concentration of drugs by hydrogel formation

被引：207

作者：

Tiller, JC ^{[1
]}

机构：

[1] Univ Freiburg, Freiburger Mat Forschungszentrum, D-79104 Freiburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 27期

关键词：

antibiotics; drug design; gels; hydrogelators; vancomycin;

D O I：

10.1002/anie.200301647

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drugs that gel: The first hydrogel-forming drug, a pyrene-derivatized form of the antibiotic vancomycin (see structure), exhibits an 11-fold higher antimicrobial activity than vancomycin itself. A possible mechanism for this effect and its influence on future drug design are discussed.

引用

页码：3072 / 3075

页数：4

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