Red-wine polyphenols and inhibition of platelet aggregation: Possible mechanisms, and potential use in health promotion and disease prevention

被引:46
作者
Halpern, MJ
Dahlgren, AL
Laakso, I
Seppanen-Laakso, T
Dahlgren, J
McAnulty, PA
机构
[1] Inst Socio Med Res, Dept Prevent Med & Nutr Sci, CH-2000 Neuchatel, Switzerland
[2] Scantox Labs, Lille Skensved, Denmark
[3] Univ Helsinki, Dept Pharm, Helsinki, Finland
关键词
polyphenols; red-wine polyphenols; ANOX (R); red wine; cardiovascular disease; platelet aggregation;
D O I
10.1177/030006059802600401
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
An extract from red-wine grape fermentation, ANOX(R) has been developed as a source of red-wine polyphenols, which are thought to inhibit several of the pathogenic pathways that lead to cardiovascular disease. New data indicate that this extract has a significantly greater effect than either red wine or red-wine powder on the inhibition of platelet aggregation in vitro. Based on this data, about 300 - 500 mg of the extract is equivalent to the daily dose of red-wine polyphenols that appears to protect against cardiovascular disease. The possible synergistic effect of red-wine polyphenols with vitamin C, their vasorelaxing activity and their possible role in preventing over-crosslinking of connective tissues (premature ageing) are considered. The extract contains standardized amounts of the whole spectrum of polyphenolic compounds found in red wine and may provide a valuable reference substance in clinical investigations of the physiological actions of plant polyphenols; its potential use in functional nutrition and preventive medicine is also discussed.
引用
收藏
页码:171 / 180
页数:10
相关论文
共 55 条
  • [1] DIETARY CARCINOGENS AND ANTICARCINOGENS - OXYGEN RADICALS AND DEGENERATIVE DISEASES
    AMES, BN
    [J]. SCIENCE, 1983, 221 (4617) : 1256 - 1264
  • [2] ENDOGENOUS OXIDATIVE DNA DAMAGE, AGING, AND CANCER
    AMES, BN
    [J]. FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 7 (3-6): : 121 - 128
  • [3] [Anonymous], DIET HLTH
  • [4] AUROMA OI, 1991, FREE RADICALS FOOD A, P201
  • [5] Baldi A, 1997, ACS SYM SER, V661, P166
  • [6] BELLIZZI MC, 1994, EUR J CLIN NUTR, V48, P822
  • [7] Boffetta P, 1990, Epidemiology, V1, P342, DOI 10.1097/00001648-199009000-00003
  • [8] CARAGAY AB, 1992, FOOD TECHNOL-CHICAGO, V46, P65
  • [9] CHAMRAI E, 1969, J PHYSIOLOGY PARIS, V61, P69
  • [10] LIPOPROTEINS AS MEDIATORS FOR THE EFFECTS OF ALCOHOL-CONSUMPTION AND CIGARETTE-SMOKING ON CARDIOVASCULAR MORTALITY - RESULTS FROM THE LIPID RESEARCH CLINICS FOLLOW-UP-STUDY
    CRIQUI, MH
    COWAN, LD
    TYROLER, HA
    BANGDIWALA, S
    HEISS, G
    WALLACE, RB
    COHN, R
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1987, 126 (04) : 629 - 637