Mitochondrial permeability transition and oxidative stress

被引：667

作者：

Kowaltowski, AJ

Castilho, RF

Vercesi, AE ^{[1
]}

机构：

[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Pathol, BR-13083970 Campinas, SP, Brazil

[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP, Brazil

来源：

FEBS LETTERS | 2001年 / 495卷 / 1-2期

关键词：

mitochondrion; calcium; reactive oxygen; free radical; thiol; cell death;

D O I：

10.1016/S0014-5793(01)02316-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial permeability transition (MPT3) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death, Although this process has a specific inhibitor, cyclosporin ri, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins, (C) 2001 Published bg Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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页码：12 / 15

页数：4

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