Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy

被引：49

作者：

Wang, Xiao-Li ^{[1
]}

Yang, Yu-Jia ^{[1
]}

Xie, Min ^{[1
]}

Yu, Xiao-He ^{[1
]}

Liu, Chen-Tao ^{[1
]}

Wang, Xia ^{[1
]}

机构：

[1] Cent S Univ, Xiang Ya Hosp, Dept Pediat, Changsha 410008, Peoples R China

来源：

NEUROREPORT | 2007年 / 18卷 / 16期

关键词：

hyperbaric oxygen; hypoxic-ischemic brain damage; neural stem cells; Wnt-3;

D O I：

10.1097/WNR.0b013e3282f0ec09

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hyperbaric oxygen therapy promoted brain cell proliferation. Wnt-3 is closely associated with the proliferation of neural stem cells. We examined whether hyperbaric oxygen promoted neural stem cells to proliferate and its correlation with Wnt-3 protein in hypoxic-ischemic neonate rats. Hyperbaric oxygen therapy was administered 3 h after hypoxia ischemia daily for 7 days. The proliferating stem cells and Wnt-3 protein were examined dynamically in the subventricular zone. Results showed that stem cells proliferated and peaked 7 days after hyperbaric oxygen therapy. Wnt-3 protein increased to the higher levels 3 days after therapy. Linear regression analysis showed that nestin protein correlated with Wnt-3 protein. We propose that hyperbaric oxygen treatment promote stem cells to proliferate, which is correlated with Wnt-3 protein. (C) 2007 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：1753 / 1756

页数：4

共 25 条

[1] Dual effect of HBO on cerebral infarction in MCAO rats
Badr, AE
Yin, W
Mychaskiw, G
Zhang, JH
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (03) : R766 - R770
[2] Effect of hyperbaric oxygen on apoptosis in neonatal hypoxia-ischemia rat model
Calvert, JW
Zhou, CM
Nanda, A
Zhang, JH
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 2003, 95 (05) : 2072 - 2080
[3] Hyperbaric oxygenation prevented brain injury induced by hypoxia-ischemia in a neonatal rat model
Calvert, JW
Yin, W
Patel, M
Badr, A
Mychaskiw, G
Parent, AD
Zhang, JH
[J]. BRAIN RESEARCH, 2002, 951 (01) : 1 - 8
[4] DAHLSTRAND J, 1992, J CELL SCI, V103, P589
[5] Recent advances in neonatology
Fawke, J
McIntyre, J
[J]. CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2002, 14 (02) : 153 - 158
[6] Neural stem/progenitor cells participate in the regenerative response to perinatal hypoxia/ischemia
Felling, RJ
Snyder, MJ
Romanko, MJ
Rothstein, RP
Ziegler, AN
Yang, ZG
Givogri, MI
Bongarzone, ER
Levison, SW
[J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (16) : 4359 - 4369
[7] Mammalian neural stem cells
Gage, FH
[J]. SCIENCE, 2000, 287 (5457) : 1433 - 1438
[8] Migration patterns of subventricular zone cells in adult mice change after cerebral cortex injury
Goings, GE
Sahni, V
Szele, FG
[J]. BRAIN RESEARCH, 2004, 996 (02) : 213 - 226
[9] Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia
Günther, A
Küppers-Tiedt, L
Schneider, PM
Kunert, I
Berrouschot, J
Schneider, D
Rossner, S
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (11) : 3189 - 3194
[10] Stage-dependent fate determination of neural precursor cells in mouse forebrain
Hirabayashi, Y
Gotoh, Y
[J]. NEUROSCIENCE RESEARCH, 2005, 51 (04) : 331 - 336

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