Immunity and protection against Brucella abortus

被引：185

作者：

Golding, B

Scott, DE

Scharf, O

Huang, LY

Zaitseva, M

Lapham, C

Eller, N

Golding, H

机构：

[1] US FDA, Div Hematol, Off Blood & Blood Res, Ctr Biol Res & Review, Rockville, MD 20852 USA

[2] US FDA, Div Viral Prod, Off Vaccines & Vaccine Res, Ctr Biol Res & Review, Rockville, MD 20852 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 01期

关键词：

Brucella abortus; T helper type 1; dendritic cells; interferon-gamma; IL-12;

D O I：

10.1016/S1286-4579(00)01350-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Brucella abortus is an intracellular pathogen that causes disease in cattle and in humans. The response against B, abortus involves the whole gamut of the immune system, from innate to adaptive immunity resulting from stimulation of antigen-presenting cells, NK cells, CD4(+) and CD8(+) T cells, and B cells. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：43 / 48

页数：6

相关论文

共 41 条

[1] Down-regulation of Th2 responses by Brucella abortus, a strong Th1 stimulus, correlates with alterations in the B7.2-CD28 pathway [J].

Agranovich, I ;

Scott, DE ;

Terle, D ;

Lee, K ;

Golding, B .

INFECTION AND IMMUNITY, 1999, 67 (09) :4418-4426

[2]

Biron CA, 1999, CURR OPIN MICROBIOL, V2, P374

[3] B70/B7-2 IS IDENTICAL TO CD86 AND IS THE MAJOR FUNCTIONAL LIGAND FOR CD28 EXPRESSED ON HUMAN DENDRITIC CELLS [J].

CAUX, C ;

VANBERVLIET, B ;

MASSACRIER, C ;

AZUMA, M ;

OKUMURA, K ;

LANIER, LL ;

BANCHEREAU, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (05) :1841-1847

[4]

Clark LB, 1996, ADV IMMUNOL, V63, P43

[5] IGG2A RESTRICTION OF MURINE ANTIBODIES ELICITED BY VIRAL-INFECTIONS [J].

COUTELIER, JP ;

VANDERLOGT, JTM ;

HEESSEN, FWA ;

WARNIER, G ;

VANSNICK, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (01) :64-69

[6] SEGMENTAL FLEXIBILITY AND COMPLEMENT-FIXATION OF GENETICALLY ENGINEERED CHIMERIC HUMAN, RABBIT AND MOUSE ANTIBODIES [J].

DANGL, JL ;

WENSEL, TG ;

MORRISON, SL ;

STRYER, L ;

HERZENBERG, LA ;

OI, VT .

EMBO JOURNAL, 1988, 7 (07) :1989-1994

[7] LACK OF A ROLE FOR NATURAL-KILLER-CELLS IN EARLY CONTROL OF BRUCELLA-ABORTUS-2308 INFECTIONS IN MICE [J].

FERNANDES, DM ;

BENSON, R ;

BALDWIN, CL .

INFECTION AND IMMUNITY, 1995, 63 (10) :4029-4033

[8] Comparison of T cell cytokines in resistant and susceptible mice infected with virulent Brucella abortus strain 2308 [J].

Fernandes, DM ;

Jiang, XS ;

Jung, JH ;

Baldwin, CL .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1996, 16 (3-4) :193-203

[9] INTERLEUKIN-LO DOWN-REGULATES PROTECTIVE IMMUNITY TO BRUCELLA-ABORTUS [J].

FERNANDES, DM ;

BALDWIN, CL .

INFECTION AND IMMUNITY, 1995, 63 (03) :1130-1133

[10]

FINKELMAN FD, 1988, J IMMUNOL, V140, P1022

← 1 2 3 4 5 →