A novel myosin heavy chain gene in human chromosome 19q13.3

被引：56

作者：

Leal, A

Endele, S

Stengel, C

Huehne, K

Loetterle, J

Barrantes, R

Winterpacht, A

Rautenstrauss, B

机构：

[1] Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany

[2] Univ Costa Rica, Inst Hlth Res, San Jose, Costa Rica

[3] Univ Costa Rica, Sch Biol, San Jose, Costa Rica

[4] Univ Erlangen Nurnberg, Inst Forens Med, D-91054 Erlangen, Germany

来源：

GENE | 2003年 / 312卷

关键词：

MYH14; non-muscle myosin; cDNA sequence; sciatic nerve; colon;

D O I：

10.1016/S0378-1119(03)00613-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A human myosin heavy chain gene was identified in chromosome 19q13 by computational sequence analysis, RT-PCR and DNA sequencing of the cDNA. The complete cDNA has a length of 6786 bp and comprises 41 exons (40 coding) included in 108 kb of genomic sequence. Alternative splicing variants were also identified. The gene is expressed in a multitude of tissues, but mainly in small intestine, colon and skeletal muscle. The putative protein (228 kDa) carries the common myosin domains and presents high homology with the nonmuscle myosin heavy chains (MYH9 and MYH10) as well as the smooth muscle myosin heavy chain MYH11. Nevertheless, phylogenetic analysis indicated that these homologous proteins are more related among themselves than to MYH14, suggesting that possibly this myosin heavy chain should be classified in a new myosin-subfamily. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：165 / 171

页数：7

共 17 条

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