A Kainate receptor increases the efficacy of GABAergic synapses

被引：107

作者：

Jiang, L ^{[1
]}

Xu, J ^{[1
]}

Nedergaard, M ^{[1
]}

Kang, J ^{[1
]}

机构：

[1] New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USA

来源：

NEURON | 2001年 / 30卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(01)00298-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain functions are based on the dynamic interaction of excitatory and inhibitory inputs. Spillover of glutamate from excitatory synapses may diffuse to and modulate nearby inhibitory synapses. By recording unitary inhibitory postsynaptic currents (uIPSCs) from cell pairs in CA1 of the hippocampus, we demonstrated that low concentrations of Kainate receptor (KAR) agonists increased the success rate (P-s) of ulPSCs, whereas high concentrations of KAR agonists depressed GABAergic synapses. Ambient glutamate released by basal activities or stimulation of the stratum radiatum increases the efficacy of GABAergic synapses by activating presynaptic KARs, which facilitate Ca2+-dependent GABA release. The results suggest that glutamate released from excitatory synapses may also function as an intermediary between excitatory and inhibitory synapses to protect overexcitation of local circuits.

引用

页码：503 / 513

页数：11

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