Bringing order to the glutamate chaos in schizophrenia

被引：315

作者：

Moghaddam, B ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA

来源：

NEURON | 2003年 / 40卷 / 05期

关键词：

D O I：

10.1016/S0896-6273(03)00757-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent genetic linkage studies complement the existing evidence that implicates abnormalities in NMDA receptor-mediated neurotransmission in the pathophysiology of schizophrenia. At the same time, advances in our understanding of the complex mechanisms that modulate the function of NMDA receptors suggest several novel sites for pharmacological manipulation of these receptors. This presents exciting opportunities for rational rather than serendipitous discovery of therapeutics for schizophrenia.

引用

页码：881 / 884

页数：4

共 29 条

[1] Association and linkage analyses of RGS4 polymorphisms in schizophrenia [J].

Chowdari, KV ;

Mirnics, K ;

Semwal, P ;

Wood, J ;

Lawrence, E ;

Bhatia, T ;

Deshpande, SN ;

K, TB ;

Ferrell, RE ;

Middleton, FA ;

Devlin, B ;

Levitt, P ;

Lewis, DA ;

Nimgaonkar, VL .

HUMAN MOLECULAR GENETICS, 2002, 11 (12) :1373-1380

[2] Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia [J].

Chumakov, I ;

Blumenfeld, M ;

Guerassimenko, O ;

Cavarec, L ;

Palicio, M ;

Abderrahim, H ;

Bougueleret, L ;

Barry, C ;

Tanaka, H ;

La Rosa, P ;

Puech, A ;

Tahri, N ;

Cohen-Akenine, A ;

Delabrosse, S ;

Lissarrague, S ;

Picard, FP ;

Maurice, K ;

Essioux, L ;

Millasseau, P ;

Grel, P ;

Debailleul, V ;

Simon, AM ;

Caterina, D ;

Dufaure, I ;

Malekzadeh, K ;

Belova, M ;

Luan, JJ ;

Bouillot, M ;

Sambucy, JL ;

Primas, G ;

Saumier, M ;

Boubkiri, N ;

Martin-Saumier, S ;

Nasroune, M ;

Peixoto, H ;

Delaye, A ;

Pinchot, V ;

Bastucci, M ;

Guillou, S ;

Chevillon, M ;

Sainz-Fuertes, R ;

Meguenni, S ;

Aurich-Costa, J ;

Cherif, D ;

Gimalac, A ;

Van Duijn, C ;

Gauvreau, D ;

Quelette, G ;

Fortier, I ;

Realson, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13675-13680

[3] Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia [J].

Clinton, SM ;

Haroutunian, V ;

Davis, KL ;

Meador-Woodruff, JH .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (06) :1100-1109

[4] Ionotropic Glutamate Receptors as Therapeutic Targets in Schizophrenia [J].

Coyle, Joseph T. ;

Tsai, Guochuan ;

Goff, Donald C. .

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2002, 1 (02) :183-189

[5] FRONTAL CORTICAL AND LEFT TEMPORAL GLUTAMATERGIC DYSFUNCTION IN SCHIZOPHRENIA [J].

DEAKIN, JFW ;

SLATER, P ;

SIMPSON, MDC ;

GILCHRIST, AC ;

SKAN, WJ ;

ROYSTON, MC ;

REYNOLDS, GP ;

CROSS, AJ .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (06) :1781-1786

[6] Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia [J].

Fujii, Y ;

Shibata, H ;

Kikuta, R ;

Makina, C ;

Tani, A ;

Hirata, N ;

Shibata, A ;

Ninomiya, H ;

Tashiro, N ;

Fukumaki, Y .

PSYCHIATRIC GENETICS, 2003, 13 (02) :71-76

[7] Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit [J].

Gerber, DJ ;

Hall, D ;

Miyakawa, T ;

Demars, S ;

Gogos, JA ;

Karayiorgou, M ;

Tonegawa, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (15) :8993-8998

[8] Genes for schizophrenia? Recent findings and their pathophysiological implications [J].

Harrison, PJ ;

Owen, MJ .

LANCET, 2003, 361 (9355) :417-419

[9]

Hirsch SR, 2003, SCHIZOPHRENIA

[10] Medicine: What are the right targets for psychopharmacology? [J].

Hyman, SE ;

Fenton, WS .

SCIENCE, 2003, 299 (5605) :350-351

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