Predictors of vascular and gastrointestinal complications in severe acute pancreatitis

Aim: To determine prognostic factors for arterial injury and gastrointestinal perforation in patients with severe acute pancreatitis (AP). Methods: A prospective cohort study was performed in 39 patients with AP whose Ranson scores were >= 3. The following parameters were assessed: Ranson score, APACHE II score, C-reactive protein (CRP) concentration on admission and on day 7, and contrast-enhanced computed tomography (CT) scans on admission (first CT) and between days 6 and 8 (second CT). The Balthazar CT severity index was calculated. Results: Six patients developed seven vascular and/or gastrointestinal complications (duodenal perforations in 3 and arterial pseudoaneurysm in 4). CRP on day 7 and the CT severity indices at the second CT were significantly higher in the complication group than in the noncomplication group. A stepwise logistic regression analysis demonstrated that CRP >= 15 mg/dl on day 7 and CT severity index >= 7 at the second CT were independent risk factors (p = 0.02 and 0.04, respectively). The odds ratio for CRP >= 15 mg/dl was 23.0 and 15.7 for a CT severity index of >= 7. Conclusion: A persistent elevation of the CRP concentration and a high CT severity index are independent risk factors for local complications associated with AP. Copyright (C) 2008 S. Karger AG, Basel and IAP.