Blackberry Extract Attenuates Oxidative Stress through Up-regulation of Nrf2-Dependent Antioxidant Enzymes in Carbon Tetrachloride-Treated Rats

被引：52

作者：

Cho, Byoung Ok ^{[1
]}

Ryu, Hyung Won ^{[1
]}

Jin, Chang Hyun ^{[1
]}

Choi, Dae Seong ^{[1
]}

Kang, Si Yong ^{[1
]}

Kim, Dong Sub ^{[1
]}

Byun, Myung-Woo ^{[2
]}

Jeong, Il Yun ^{[1
]}

机构：

[1] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 580185, Jeonbuk, South Korea

[2] Woosong Univ, Dept Culinary Nutr, Taejon 300718, South Korea

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2011年 / 59卷 / 21期

关键词：

blackberry; carbon tetrachloride; oxidative stress; antioxidant enzyme; lipid peroxidation; NF-E2-related factor-2 (Nrf2); SIGNALING PATHWAY; ANTHOCYANIN; INHIBITION; CANCER; DAMAGE; LIVER; BARK;

D O I：

10.1021/jf2021804

中图分类号：

S [农业科学];

学科分类号：

082806 [农业信息与电气工程];

摘要：

The aim of this study was to investigate the protective ability Of blackberry extract (BE),against oxidative stress in carbon tetrachloride (CCl4)-treated rats The results showed that treatment with BE attenuated lipid peroxidation that was increased by CCl4 and also markedly recovered the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), that were decreased by CCl4 BE also elevated the protein expression levels of NF-E2-related factor-2 (Nrf2), CuZnSOD, MnSOD, GPx-1/2, and heme oxygenase-1 (HO-1), but not that of catalase Furthermore, the administration of BE significantly attenuated the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) that were increased by CCl4 Therefore, the present study suggests that BE possesses significant protective effects against in vivo oxidative stress

引用

页码：11442 / 11448

页数：7

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