Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis

被引：24

作者：

Boutin, SR

Shen, ZL

Rogers, AB

Feng, Y

Ge, ZM

Xu, S

Sterzenbach, T

Josenhans, C

Schauer, DB

Suerbaum, S

Fox, JG

机构：

[1] MIT, Div Comparat Med, Cambridge, MA 02139 USA

[2] MIT, Div Biol Engn, Cambridge, MA 02139 USA

[3] Hannover Med Sch, Inst Med Microbiol & Hosp Epidemiol, D-3000 Hannover, Germany

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 12期

关键词：

D O I：

10.1128/IAI.73.12.8449-8452.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one of three strains of H. hepaticus: type strain Hh3B1, which contains the complete PAI, and strains HhNET and HhG, which lack all or large parts of HHGI1, respectively. Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1.

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收藏

页码：8449 / 8452

页数：4

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