Amphilactams A-D:: Novel nematocides from southern Australian marine sponges of the genus Amphimedon

被引：33

作者：

Ovenden, SPB

Capon, RJ ^{[1
]}

Lacey, E

Gill, JH

Friedel, T

Wadsworth, D

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3052, Australia

[2] Microbial Screening Technol PTY LTD, Kemps Creek, NSW 2171, Australia

[3] Novartis Anim Hlth Asutralasia PTY Ltd, Kemps Creek, NSW 2171, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 04期

关键词：

D O I：

10.1021/jo981377e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-directed fractionation of the ethanol extracts of two Amphimedon spp. collected during trawling operations in the Great Australian Eight yielded four new macrocyclic lactone/lactams, amphilactams A-D (1-4). The amphilactams possess potent in vitro nematocidal properties, and their structures were assigned on the basis of detailed spectroscopic analysis and comparison with synthetic model compounds. The amphilactams feature both carbon skeletons and an enamino lactone/lactam moiety unprecedented in the natural products literature.

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页码：1140 / 1144

页数：5

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