Respiratory syncytial virus vaccine development

被引：48

作者：

Crowe, JE

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37232 USA

来源：

VACCINE | 2001年 / 20卷

关键词：

respiratory syncytial virus (RSV); parainfluenza virus (PIV); vaccines;

D O I：

10.1016/S0264-410X(01)00287-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of an RSV vaccine for infants has been hindered by the lack of an ideal animal model that exhibits disease, and the challenge of effectively immunizing very young infants who are immunologically immature. Nevertheless, significant progress has been made recently in developing live attenuated viruses and protein subunit vaccine candidates. Numerous vaccine candidates are currently in early clinical trials. This paper reviews the significant obstacles to development of RSV vaccines, and the progress made to date. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：S32 / S37

页数：6

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